GIRK Channel Activation Involves a Local Rearrangement of a Preformed G Protein Channel Complex
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GIRK Channel Activation Involves a Local Rearrangement of a Preformed G Protein Channel Complex
G protein-coupled signaling is one of the major mechanisms for controlling cellular excitability. One of the main targets for this control at postsynaptic membranes is the G protein-coupled potassium channels (GIRK/Kir3), which generate slow inhibitory postsynaptic potentials following the activation of Pertussis toxin-sensitive G protein-coupled receptors. Using total internal reflection fluor...
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(PTX)-sensitive G␣ i/o proteins activate GIRK (Wickman and Pharmacology and Clapham, 1995); the preferred donors of G␥ are University of Texas G␣ i2 and G␣ i3 but not G␣ o (Kozasa et al., 1996; Sowell Houston Medical School et al., 1997). We have previously found that, in excised Houston, Texas 77030 patches of Xenopus oocytes, G ␥-induced GIRK activation is antagonized by GTP␥S-activated G␣ ...
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ژورنال
عنوان ژورنال: Neuron
سال: 2006
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2006.08.017